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The Genes, Girls, and Gamow subseries consists of manuscripts, typescripts and galleys of Watson's 2002 memoir. The subseries also includes correspondence with publishers, comments on the manuscript, and reviews.

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The DNA: Secret of Life subseries consists of manuscripts, typescripts and galleys of Watson's book (co-authored with Andrew Berry). The subseries also includes correspondence with publishers, comments on the manuscript, and reviews.

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The Recombinant DNA, 2nd Edition subseries consists of chapter outlines and correspondence with publishers.

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The Recombinant DNA, 1st Edition subseries consists of manuscripts, typescripts and galleys of Watson's textbook.

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The DNA Story subseries consists of manuscripts, typescripts and galleys of Watson's book (Co-authored by John Tooze). The subseries also includes correspondence with publishers.

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The Molecular Biology of the Cell subseries consists of manuscripts, typescripts and galleys of Watson's textbook. The subseries also includes correspondence with publishers, reactions to the book, and reviews.

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The Double Helix subseries consists of typescripts and galleys of Watson's famous memoir. The subseries also includes correspondence with publishers, reactions to the book, and reviews.

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The Molecular Biology of the Gene, 5th Edition subseries consists of manuscripts, typescripts, and galleys of the fifth edition of Watson's famous textbook. The subseries also includes correspondence with publishers and the other authors.

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The Molecular Biology of the Gene, 4th Edition subseries consists of manuscripts, typescripts, and galleys of the fourth edition of Watson's famous textbook. The subseries also includes correspondence with publishers.

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The Molecular Biology of the Gene, 3rd Edition subseries consists of manuscripts, typescripts, and galleys of the third edition of Watson's famous textbook. The subseries also includes correspondence with publishers.

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